薛璐璐博士，BETWAY必威/附属鼓楼医院准聘副教授、研究员、至诚青年教授，博士生导师。获国家高层次青年项目（海外）资助（2024）。2020年于德国萨尔大学/莱布尼茨新材料研究所获得博士学位，2021年-2024年在美国宾夕法尼亚大学（UPenn）生物工程系进行博士后研究（合作导师：Michael J. Mitchell)。2024年12月加入顾宁院士领导的工程医学（Engineering Medicine) 研究组。聚焦于多尺度核酸药物器官特异性递送与转化，围绕基于微纳生物材料、mRNA药物递送技术和基因/免疫治疗开展生物医学工程方向的研究。以第一（含共同第一）和通讯作者在Nature Nanotechnology, Nature Reviews Materials, Nature Reviews Chemistry，Nature Materials, Nature Communications, Science Translational Medicine, JACS, PNAS，Angew Chem等领域内主流期刊发表论文多篇，被美国生物材料学会（Society for Biomaterials)授予BWF Biointerfaces Rising Award（2024），并受邀在BioInterfaces SIG session上作特邀报告（keynote speaker）。申请专利9项，包括PCT国际专利3项，并授权给生物科技公司做转化研究。

长期招聘博士后和科研助理，热忱欢迎对生物材料、纳米药物、基因治疗等感兴趣的员工前来攻读硕士、博士学位或进行短长期学术交流。期待具有药学、化学、材料、生物、医学等研究兴趣和背景的青年才俊加入！

联系邮箱：lulxue@nju.edu.cn

Advanvced Interventional Materialsbi、Biomedicines编委

Expoloration、The Innovation Medicine青年编委

Discover Chemistry客座编辑

Nature Biomedical Engineering、Science Translational Medicine、Science Advances、Nature Communications、Journal of the American Chemical Society、Angewandte Chemie International Edition、ACS Nano、Bioactive Materials、Journal of Nanotechnology、Journal of Controlled Release等期刊独立审稿人

1. Z. Gu, X. Xiong, X. Chen, H. Zhang, N. Gu and L. Xue*. Ligand-Mediated Reprogramming Redirects Liver-Tropic Ionizable Lipid Nanoparticles for Lung-Selective mRNA Delivery. Angew. Chem. Int. Ed., 2026, e608066 (*: corresponding author).

2. L. Xue*, M. Ang, K. Swingle, E. Fitzgerald, O. Chalom, N. Gu and M. Mitchell. Structural Evolution of Ionizable Lipids for Nucleic Acid Delivery. Nat. Rev. Chem., 2026, In Press (*: corresponding author).

3. L. Xue, A. Thatte, D. Mai, R. Haley, N. Gong, X. Han, N. Sheppard, C. June and M. Mitchell. Responsive Biomaterials: Optimizing Control of Cancer Immunotherapy. Nat. Rev. Mater., 2023, 9, 100.

4. L. Xue, G. Zhao, N. Gong, X. Han, S. Shepherd, X. Xiong, J. Xu, K. Swingle, C. Warzecha, R. El-Mayta, J. Xu, J. Cui, Y. Shi, M. Alameh, K. Wang, L. Wang, D. Pochan, D. Weissman, A. Vaughan, J. Wilson and M. Mitchell. Combinatorial Design of Siloxane Incorporated Lipid Nanoparticles Augment Tntracellular Processing for Tissue-Specific mRNA Therapeutic Delivery. Nat. Nanotechol., 2025, 20, 132.

5. L. Xue, K. Swingle, and M. Mitchell. Small Structural Changes in Siloxane-Based Lipidoids Improve Tissue-Specific mRNA Delivery. Nat. Nanotechnol., 2025, 20, 12.

6. L. Xue, A. Hamiton, G. Zhao, R. El-Mayta, X. Han, N. Gong, X. Xiong, J. Xu, C. Figueroa-Espada, S. Shepherd, A. Mukalel, M. Alameh, J. Cui, K. Wang, A. Vaughan, D. Weissman and M. Mitchell. High-Throughput Barcoding of Nanoparticles Identifies Cationic, Degradable Lipid-Like Materials for mRNA Delivery to the Lungs in Female Preclinical Models. Nat. Commun., 2024, 15, 1884.

7. L. Xue,X. Xiong, G. Zhao, W. Molina-Arocho, R. Palanki, Z. Xiao, X. Han, I. Yoon, C. Figueroa-Espada, J. Xu, N. Gong, Q. Shi, Q. Chen, M. Alameh, A. Vaughan, M. Haldar, K. Wang, D. Weissman and M. Mitchell. Multiarm-Assisted Design of Dendron-Like Degradable Ionizable Lipids Facilitate Systemic mRNA Delivery to the Spleen. J. Am. Chem. Soc.,2025, 147, 1542.

8. L. Xue, N. Gong, S. Shepherd, X. Xiong, X. Liao, X. Han, G. Zhao, C. Song, X. Huang, H. Zhang, M. Padilla, J. Qin, Y. Shi, M. Alameh, D. Pochan, K. Wang, F. Long, D. Weissman and M. Mitchell. Rational Design of Bisphosphate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment. J. Am. Chem. Soc.,2022, 144, 9926-9937 .

9. L. Xue, X. Xiong, B. Krishnan, F. Puza, S. Wang, Y. Zheng and J. Cui. Light-Regulated Growth from Dynamic Swollen Substrates for Making Rough Surfaces. Nat. Commun., 2020, 11, 963.

国家级青年人才项目（海外）2025-2027

中央高校基本科研业务费 2026-2027

BETWAY必威国际科研合作种子基金 2026-2028

BWF BioInterface Rising Star Award （2024），美国生物材料学会